SNAP 94847 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SNAP 94847 Hydrochloride 是一种黑色素浓缩激素受体 1 (MCHR1) 拮抗剂 (Ki= 2.2 nM)。

SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM).

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SNAP 94847 hydrochloride (oral gavage; 20?mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment:?F(2,19)=11.31,?treatment?×?time:?F(34,323)?=?4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals.SNAP 94847 hydrochloride (oral administration; 20?mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment:?F(3,28)?=?8.971; treatment?×?time:?F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40?min in the SNAP 94847-treated group,this effect is significant over 180?min.SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study. Animal Model:RatDosage:20 mg/kg Administration:Oral administration; 20 mg/kg; 14 days Result:Exhibited a exaggerated locomotor response to acute quinpirole.Animal Model:Rat Dosage:10 mg/kg Administration:Oral administration; 10 mg/kg Result:Exhibited good physicochemical properties in rats.

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GPCR/G Protein

MCHR

MCH1-R

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1781934-47-1

515.03

C29H33ClF2N2O2

>98% (HPLC)

DMSO:250 mg/mL (485.41 mM; Need ultrasonic)

Cc1ccc(NC(=O)C(C)C)cc1C1CCN(Cc2ccc(Oc3ccc(F)c(F)c3)cc2)CC1.Cl

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(-20℃)

With Ice Pack

≥ 2 years